Department:School of Life Sciences
Havovi’s primary research focuses on cellular mechanisms which regulate the endothelium in human disease.
In 2011, Havovi earned her doctorate in physiology from University College London, which focused on studying the role of renal and small intestinal glucose transport across the epithelium in metabolic syndrome and diabetes. During her studies, she developed an interest in the microvasculature complications associated with diabetes and took advantage of the opportunity to perform postdoctoral research at the Vascular Research Laboratory in Brown University.
As a postdoctoral fellow, Havovi's research developed into vascular dysfunction in settings of disease including respiratory disease. During her postdoctorate, she was awarded significant funding from the American Heart Association, published several peer-reviewed articles and participated in numerous clinical and basic research conference presentations (including invited and peer-reviewed oral presentations) on renal glucose transport, endocytosis, vascular function and respiratory disease.
MSc Applied Bioscience
BSc (Hons) Biomedical Science
Module Leader for Human Anatomy and Physiology 1
Module Leader for Physiology of Organ Systems
Harrington EO, Vang A, Braza A, Chichger H. Activation of the sweet taste receptor, T1R3, by the artificial sweetener sucralose regulates the pulmonary endothelium. American Journal of Physiology – Lung Cellular and Molecular Physiology. (2018) 314 (1):L165. Link
Vang A, Clements RT, Chichger H, Kue N, Allawzi A, O’Connell K, Jeong EM, Dudley SC Jr, Sakhatskyy P, Lu Q, Zhang P, Rounds S, Choudhary G. Effect of alpha7 nicotinic acetylcholine receptor activation on cardiac fibroblasts: a mechanism underlying RV fibrosis associated with cigarette smoke exposure. American Journal of Physiology – Lung Cellular and Molecular Physiology. (2017) 312 (5):L748. Link
Chichger H, Cleasby M, Srai KS, Debnam ES, Unwin R.J, Marks J. Differential regulation of renal glucose transporters: Implications for diabetic nephropathy. Experimental Physiology. (2016) 101 (6):731-42. Link
Chichger H, Braza J, Duong H, Boni G, Harrington EO. Select Rab GTPases regulate the pulmonary endothelium via endosomal trafficking of VE-cadherin. American Journal of Respiratory Cell and Molecular Biology. (2016) 54 (6):739-81. Link
Chichger H, Braza J, Duong H, Stark M, Harrington EO. Neovascularization in the pulmonary endothelium is regulated by the endosome: Rab4-mediated trafficking and p18-dependent signaling. American Journal of Physiology – Lung Cellular and Molecular Physiology. (2015) 309 (7):L700. Link
Chichger H, Vang A, O’Connell K, Zhang P, Harrington EO, Mende U, Choudhary G. PKC δ and βII Regulate Angiotensin II Mediated Fibrosis through p38: A Mechanism of RV Fibrosis in Pulmonary Hypertension. American Journal of Physiology – Lung Cellular and Molecular Physiology. (2015) 308 (8):L827-36. Link
Chichger H, Braza J, Duong H, Harrington EO. p18, a novel adaptor protein, regulates pulmonary endothelial barrier function via enhanced endocytic recycling of VE-cadherin. FASEB J. (2015) 29 (3):868-81. Link
Chichger H, Braza J, Duong H, Harrington EO. SHP2 and FAK protein interactions regulate pulmonary endothelium barrier function. American Journal of Respiratory Cell and Molecular Biology. (2015) 52 (6):695-707. Link
Jacquillet G, Chichger H, Unwin RJ, Shirley DG. Luminal proteolytic activation of the collecting duct epithelial sodium channel (ENaC) and its possible role in renal sodium reabsorption in vivo. Nephrology Dialysis Transplantation. (2013) 28 (4):839-45. Link
Bitter taste receptors regulate microvascular permeability. International Vascular Biology Organisation conference, Helsinki, June 2018.
The Role of Taste Sensing in the Pulmonary Endothelium. NHLBI Research Seminar, Imperial College London, June 2018.
Activation of the sweet taste receptor attenuates VEGF-induced angiogenesis. Diabetes UK Professional Conference, London, March 2018.
Artificial Sweetener Sucralose Protects the Pulmonary Endothelium from LPS-induced permeability. American Thoracic Society conference, San Francisco, May 2016.
Endosomal proteins p18 and Rab4 are differentially regulated in pulmonary hypertension and COPD/emphysema. American Thoracic Society conference, San Francisco, May 2016.
Novel Regulation of the Pulmonary Endothelium. Cambridge Cardiovascular Research Seminar, Cambridge University, October 2015.
The Endosome in Pulmonary Disease. Rhode Island Hospital Clinical Pulmonary Seminar, Brown University, February 2015.
A Role for the Endosome in Angiogenesis: Implications for Pulmonary Arterial Hypertension. Vascular Research Laboratory Seminar, Providence Veteran Affairs Medical Center, Providence, RI, October 2014.
Over 30 published abstracts from conferences in journals ranging from Proceedings of the Physiological Society, Journal of American Society of Nephrology, Genes & Nutrition, FASEB Journal and American Journal of Respiratory and Critical Care Medicine.
Autumn 2018: Article in Physiology News on mobility in science (issue 11, page 24) Link
19th March 2018: Article in The Conversation based on physiological roles of artificial sweeteners Link
29th January 2018: Feature on artificial sweeteners on the BBC One ‘Food Truth or Scare’ television program (episode 1) Link
May 2016: several media outlets, including TIME magazine, Independent newspaper and Science daily online, covered research from the Experimental Physiology publication based on the role of the junk-food diet on kidney function.
10th May 2016: interview on KCBS radio (USA) regarding the Experimental Physiology publication