Faculty:Faculty of Science & Technology
Department:Biomedical and Forensic Science
Paul is a Senior Lecturer in Biomedical Science and HCPC registered Biomedical Scientist. His research aim to develop the application of biological nanoparticles and exosomes as novel biomarkers and drug delivery agents.
Paul Joined the Department of Biomedical and Forensic Science as a Senior Lecturer in November 2017. Prior to this, he was a Principal Lecturer in the Department of Life and Sport Science at the University of Greenwich.
Paul has a strong background in Biomedical Science education and training having worked in both the NHS as a state registered Biomedical Scientist and HE sector teaching at both undergraduate and postgraduate levels.
Upon completing his PhD in 2014, Paul has been expanding upon his research in:
He is currently engaged in developing his research group in the Applied Exosomes (ApEx) Research Laboratory, which aims to further enhance our understanding of exosomes and microvesicles, realising their potential as novel diagnostic biomarkers and personalised medicines.
BSc (Hons) Biomedical Science
Module Leader for Diagnostic Techniques in Pathology
Module Leader for Preparation for Research
MSc Biomedical Science (Distance Learning)
Module Leader for Cellular Haematology
Module Leader for Haemostasis and Blood Transfusion
PhD Cell Biology and Drug Delivery - University of Greenwich (2014)
MSc Haematology (Blood Transfusion) - University of Westminster (2001)
BSc (Hons) Biomedical Science - University of Bradford (1997)
Science and Technology Facilities Council (STFC) (2017). Investigation of the translocation potential of therapeutic macromolecules into cell derived exosomes: RB1710290. 4 Days beam time at ISIS/RAL – In-kind value ~£72, 000
Institute Langevin –Laue (ILL), Grenoble (2016). Determination of the presence of deuterated lethal factor in cell derived exosomes using SANS and neutron reflectometry: 8-02-786. 4 Days total beam time requested – In-kind value £60, 000
University of Greenwich, Competitive REF allocation (2016). Characterisation of two-pore-domain potassium (K2P) channels in direct association with putative therapeutic agents, using novel nanodisc technology. £18, 000
Medway School of Pharmacy, University of Kent PhD Studentship (2016). Characterisation of two-pore-domain potassium (K2P) channels in direct association with putative therapeutic agents, using novel nanodisc technology. £45, 000
Science and Technology Facilities Council (STFC) (2016). Investigation of the solution structure and pore dynamics of Bacillus anthracis protective antigen stabilised in lipid nanodiscs: RB1610353. 4 Days beam time at ISIS/RAL – In-kind value £72, 000
Institute Langevin –Laue (ILL), Grenoble (2015). Investigation of PA pore translocation through lipid nanodiscs using SANS and neutron reflectometry: 8-03-848. 3 Days beam time at ILL – In-kind value £45, 000
University of Greenwich, Department Investment Fund (2014). EVOS FLoid Cell Imaging Station to enhance student learning, experience and outreach - £25, 000
University of Greenwich, Department Investment Fund (2014). Investigation of protein production, purification and characterisation by HSDSC, Kinetic CD, SANS and Neutron Reflectometry - £25, 000
Greenwich Research and Enterprise: Research and Enterprise Investment Programme (2008). Characterisation of a novel RNAi delivery system. £14, 857
Rai, R., Dyer, P., Richardson, S., Harbige, L., & Getti, G., 2017. Apoptotic induction induces Leishmania aethiopica and L. mexicana spreading in terminally differentiated THP-1 cells. Parasitology, 144(14), pp1912-1921. doi:10.1017/S0031182017001366
Shorter S. A., Pettit M. W., Dyer P. D. R., Coakley-Youngs J. E., Gorringe-Pattrick M. A. M., El-Daher S. and Richardson S. C. W., 2017. Green Fluorescent Protein (GFP): is seeing believing and is that enough? Journal of Drug Targeting, 25(9-10), pp809-817 doi:10.1080/1061186X.2017.1358725
Paul D. R. Dyer, Arun K Kotha, Alexander S Gollings, Susan A Shorter, Thomas R Shepherd, Marie W Pettit, Bruce D. Alexander, Giulia T Getti, Samer El-Daher, Les Baillie, Simon C. W. Richardson, 2016. An in vitro evaluation of epigallocatechin gallate (eGCG) as a biocompatible inhibitor of ricin toxin. Biochimica et Biophysica Acta (BBA), 1860(7), pp1541-50 doi:10.1016/j.bbagen.2016.03.024
Shorter S.A., Gollings A.S., Gorringe-Pattrick M.A.M., Coakley J.E., Dyer P.D.R. and Richardson S.C.W., 2016. The potential of toxin-based drug delivery systems for enhanced nucleic acid therapeutic delivery. Expert Opinion on Drug Delivery, 14(5), pp685-696, doi:10.1080/17425247.2016.1227781
Paul D.R. Dyer, Thomas R. Shepherd, Alexander S. Gollings, Susan A. Shorter, Monique A.M. Gorringe-Pattrick, Chun-Kit Tang, Beatrice N. Cattoz, Les Baillie, Peter C. Griffiths, Simon C.W. Richardson, 2015. Disarmed anthrax toxin delivers antisense oligonucleotides and siRNA with high efficiency and low toxicity. Journal of Controlled Release, 220(Part A), pp316-328. doi:10.1016/j.jconrel.2015.10.054
Marie W. Pettit, Paul D.R. Dyer, John C Mitchell, Peter C Griffiths, Bruce Alexander, Beatrice Cattoz, Richard K Heenan, Stephen M King, Ralf Schweins, Frank Pullen, Stephen R Wicks, and Simon C W Richardson, 2014. Construction and physiochemical characterisation of a multi-composite, potential oral vaccine delivery system (VDS). International Journal of Pharmaceutics, 468(1-2), pp264-271. doi:10.1016/j.ijpharm.2014.03.046
Paul D. R. Dyer, Arun K. Kotha, Marie W.Pettit, Simon C. W. Richardson, 2013. Imaging Select Mammalian Organelles Using Fluorescent Microscopy: Application to Drug Delivery. In Cellular and subcellular nanotechnology: methods and protocols; Methods in Molecular Biology, Humana Press ISBN: 978-1-62703-336-7. doi:10.1007/978-1-62703-336-7_19
P.C. Griffiths, N. Mauro, D.M. Murphy, E. Carter, S.C. Richardson, P. Dyer and P. Ferruti, 2012. Self-assembled PAA-based nanoparticles as potential gene and protein delivery systems. Macromolecular Bioscience, 13(5), pp641–649. doi:10.1002/mabi.201200462
Dyer P.D.R. and Richardson S.C.W.*, 2011. Delivery of biologics to select organelles - the role of biologically active polymers. Expert Opinion on Drug Delivery, 8(4), pp403-7. doi:10.1517/17425247.2011.558080
15th Medical Biodefense Conference. Munich, Germany, 28 April 2016. Invited speaker. An evaluation of epigallocatechin gallate (eGCG) as a biocompatible inhibitor of ricin and Clostridium difficile toxins. Dyer, P., Shorter, S., Richardson, S.C.W., and Baillie, L.