Improving global cardiometabolic health: Perspectives on prediction, precision, prevention, personalised, population and policy

4 October 2016, 14:00 - 15:00
Health Building, Young Street, Cambridge, CB1 2LZ

Prof Simin Liu head shot
Untitled Page

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Anglia Ruskin University welcomes Prof Simin Liu, Professor of Epidemiology and Medicine and Director at the Center for Global Cardiometabolic Health, Brown University, to the Cambridge Campus on October to give an exciting talk on Improving global cardiometabolic health.

In the past 50 years, human lifespan has increased bu almost 50 % whilst the rising burden of age-related diseases has become staggering in the same period. Individuals with chronic disease now consume >80% of all healthcare spending. According to the latest American Heart Association (AHA)'s Heart Disease and Stroke Statistics (2015), approximately half of the entire US population will have some form of ASCVD with direct medical costs surpassing >$1 trillion (using current $ value) by 2030. Of the total cost directly related to ASCVD, 61% is projected for hospital stays, 16% medications, and 24% physicians/ nursing home, and home health care costs. In parallel, indirect costs (attributable to lost productivity) due to ASCVD are estimated to increase by 58%. Set against this depressing projection however, is decades of epidemiologic investigation demonstrating that 80-90% ASCVD can be prevented via lifestyle and dietary interventions. Recent data from both observational cohorts and experimental studies have shown that effective medical interventions and controls of risk factors have dramatically reduced ASCVD incidence in the US (ie, by 50% from 1980 to 2000, and additional 33% from 1999 to 2009).

How can we reconcile such contrasting views toward the future of cardiovascular health in human populations?

In this presentation, Prof Simin Liu shall review available sources of evidence that can be used to answer these challenging questions of why and how. He will submit that we could end the current ASCVD epidemics in human populations if we can shift focus and resources toward developing multi-levels systems' approaches for prevention. Such focus needs to be implemented across the entire lifespan during which effective and well-established intervention effort at each phase of the time-dependent process in the ASCVD development can be introduced to target populations at risk. Specific strategies to be prioritised include -

1) Addressing global ASCVD health and disease disparities
2) Preventing and reversing atherosclerosis before middle age
3) Preventing thrombosis by controlling triggering risk factors while promoting quality of life in aging individuals
4) Promoting precision medicine and prevention to every family via education in genomics and family history

To reach the ultimate goal of reducing ASCVD incidence by another 50% by 2050, almost one century after it peaked as mankind's No 1 Killer; Prof Simin Liu will also identify several gaps in our knowledge base for which research must address -

1) How do we standardise and scale up public health effort by completely shifting the focus on prevention with global public support?
2) What specific strategies could be best individualised and personalised in the process of prevention and intervention so that individuals from diverse social-economic and cultural background are most engaged for a common good?
3) How do we individualise heart healthy lifestyles and habits that could be adapted via the most cutting-edge technological advances in a sustainable manner as a public good?

Shifting the resource focus to prevention is challenging, so is predicting the future health of human population. The best way to achieve it is to create one and we should start now.

Event Details

4 October 2016, 14:00 - 15:00
Health Building, Young Street, Cambridge, CB1 2LZ
Lecture Theatre 218
Free to attend