Myopia research

Professor Shahina Pardhan, Dr Peter Allen, Dr Sheila Rae, Dr Richard Calver, Dr Silvia Cirstea, Dr Holly Price, Heather Shorrock, Dr Ian van der Linde, Dharani Ramamurthy. Collaboration between Myopia and Visual Function group, Department of Optometry and Ophthalmic Dispensing and Department of Computing and Technology. 

Current activities

  • To identify optical factors that are associated with myopic progression

  • To investigate how ocular biometry and eye shape are associated with myopic progression

  • To investigate how optical and biometric factors relate to the progression of myopia.

  • To investigate how family history, IQ and near-work affects myopia progression.

  • To identify the role of peripheral refraction in Myopia.

Outcomes

We have investigated factors related to the accommodation system both cross-sectionally and longitudinally in myopes. Our researchers have identified reasons for such deficits in accommodation and were the first to show that reduced accommodative response in myopes may be due to a decrease in sensitivity to negative lens blur, and that the optimum focus for a system which drives accommodation is more negative in myopes. 
We are investigating potential treatments for myopia, mainly vision training and specially designed contact lenses to improve the accuracy of accommodation during near-work. Our preliminary data of three months of treatment indicate that the treatment has been successful in improving the accommodative responses of myopes. We are the first ones to show that accommodative facility and lag of accommodation are independently associated with the progression of myopia in young adults.
Recently, the contribution of peripheral refractive error to myopia progression has received a great deal of attention, and we have contributed to this debate by demonstrating how these errors vary in the nasal and temporal retina in distance and near vision. Our study in India has examined the interaction between family history of myopia and amount of near-work, showing that myopes with a family history of myopia progress more than those without, and also highlighting association between myopia and IQ scores.
The group is part of a large research consortium based in Australia and funded by the government of Australia (the Vision Co-operative Research Centre) with international research partners in the University of Houston, Queensland University of Technology, the University of Sydney, University of Melbourne, the University of New South Wales, the Pennsylvania College of Optometry, Manchester University and Sankar Netralaya Hospital (Chennai), LV Prasad Institute in India. 

Grants

  • Vision CRC to the Myopia Research Group through the Government of Australia Research Co-operative grant (£201,301).

  • University of California, Berkeley Clinical Scientists Development Program travel grant award.

  • Vision CRC travel grants. 

Publications

Allen, P.M., Radhakrishnan, H., Price, H., Rae, S., Theagarayan, B., Calver, R.I., Sailoganathan, A., Latham, K. and O?Leary, D.J. (2013). A randomised clinical trial to assess the effect of a dual treatment on myopia progression: The Cambridge Anti-Myopia Study. Ophthalmic and Physiological Optics (accepted for publication).
Radhakrishnan, H., Allen, P.M., Calver, R.I., Theagarayan, B., Price, H., Rae, S., Sailoganathan, A., and O?Leary, D.J. (2013). Peripheral refractive changes associated with myopia progression. Investigative Ophthalmology and Visual Science (accepted for publication).