16 November 2017, 12:00 - 14:00
ARITI is delighted to welcome Dr Nabila Kazmi who is a Senior Research Associate at the MRC Integrative Epidemiology Unit, University of Bristol. She will present her seminar 'Hypertensive disorder of pregnancy and future risk of cardiovascular disease'.
Dr Kazmi’s presentation followed by a Q&A session will take place 12-1pm. Lunch and networking will take place 1-2pm.
Women with hypertensive disorders of pregnancy (HDP), especially preeclampsia have an increased risk of cardiovascular disease (CVD) in their later life and it now appears that their offspring may also be at a higher risk of cardiovascular health. The integration of emerging omics technologies such as epigenetics, transcriptomics and metabolomics can help to understand the key biological variation that results in the increased risks of CVD in this large cohort (offspring of mothers with HDP). This talk will present Dr Kazmi's research, which aims to investigate the associations between one of the epigenetics mechanism such as DNA methylation and HDP using ten independent birth cohorts (n=5242) from the Pregnancy and Childhood Epigenetics Consortium. HDP was seen associated with differential methylation at cord-blood sites across the genome. Some genes previously known to be involved in cardiovascular diseases have now been found. Pathway analyses suggested several of these sites are involved in developmental, embryogenesis or neurological pathways.
Dr Nabila Kazmi is a Senior Research Associate at the MRC Integrative Epidemiology Unit, University of Bristol. Her research interests and expertise are in bioinformatics, computational biology, machine learning, epigenetics epidemiology to understand determinants and consequences of adverse pregnancy outcomes. In particular, she is interested to identify molecular pathways that are linked to CVD.