Dr Linda King

Deputy Head of Department

Faculty:Faculty of Science & Technology

Department:Biomedical and Forensic Science

Location: Cambridge

Areas of Expertise: Life sciences

Linda’s background is in pathophysiology and biochemistry, specifically focused on myocardial ischaemia and perturbations in glucose metabolism.

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linda.king@anglia.ac.uk

Background

Linda has taught a number of subjects over several years at both the University of Cambridge and Anglia Ruskin University, including physiology, cell biology, biochemistry and genetics. She is module leader for Human Anatomy and Physiology 1 and the Physiology of Organ Systems, and involved in teaching across a number of other modules including Molecular Cell Biology, Medical Genetics, Core Biology, Human Anatomy and Physiology 2 and Human Pathology.

Areas of research supervision

  • Metabolic changes in ischaemic heart disease and diabetes: changes in the insulin signalling cascade brought about by accumulation of fatty acids, and effects on glucose metabolism
  • G-protein coupled receptors - transcription, movement through the endomembrane system and function at the cell membrane, using the melanocortin 1 receptor as a model of function
  • PhD supervision – Lipotoxicity-induced changes in insulin signalling
  • Alterations in MC1R signalling

Qualifications

  • BSc (Hons) in Physiology and Genetics, University of the Witwatersrand
  • MSc Medicine, University of Cape Town
  • PhD Medicine, University of Cape Town
  • PGCert in Higher Education and Learning, Anglia Ruskin University

Selected recent publications

McRobie, H., King L., Symmons M., Fanutti C., and Coussons, P., 2014. Agouti Signalling Protein is an Inverse Agonist to the Wildtype and Agonist to the Melanic Variant of the Melanocortin- 1 Receptor in the Grey Squirrel (Sciurus Carolinensis). FEBS Letters, 588, pp.2335-2343.

McRobie, H., King, L.M., Fanutti, C., Coussons, P. and Thomas, A., 2014. Variation in the melanocortin 1 receptor (MC1R) gene in the grey, fox and red squirrels: melanism is not associated with variation of the MC1R in the red and fox squirrel. Journal of Heredity, 105(3), pp.423–428.

Desrois, M., Sidell, R.J., Gauguier, D., King, L.M., Radda, G.K. and Clarke, K., 2004. Initial steps of insulin signaling and glucose transport are defective in the type 2 diabetic rat heart. Cardiovascular Research, 61, pp.288-296.

King, L.M. and Wilkins, M.R., 2002. Natriuretic peptide receptors and the heart. Heart, 87, pp.314-315.

King, L.M., Sidell, R.J., Wilding, J.R., Radda G.K. and Clarke, K., 2001. Free fatty acids, but not ketone bodies, protect diabetic rat hearts during low-flow ischemia. American Journal of Physiology. Heart and Circulatory Physiology, 280(3), H1173-H1181.

Hopkins, J.C.A., Bia, B., Crilley, J.G., Boehm, E.A., Sang, E.A., Tinsley, J.A., King, L.M., Radda, G.K., Davies, K.E. and Clarke, K., 2000. Muscular dystrophy: from gene to patient. Magnetic Resonance Materials in Physics, Biology and Medicine, 11, pp.7-9.

King, L.M., Sidell, R.J., Jones, B.E., Radda, G.K., Clarke, K., 1998. Fatty acids, ischaemic damage and the diabetic heart. Magnetic Resonance Materials in Physics, Biology and Medicine, 6, pp.173-174.

Taegtmeyer, H., King, L.M., Jones, B.E., 1998. Energy substrate metabolism, myocardial ischemia, and targets for pharmacotherapy. American Journal of Cardiology, 82 (Suppl 1), 54K-60K.

King, L.M. and Opie, L.H., 1998. Glucose delivery is a major determinant of glucose utilisation in the ischemic myocardium with a residual coronary flow. Cardiovascular Research, 39, pp381-392.

King, L.M. and Opie, L.H., 1998. Glucose and glycogen utilisation in myocardial ischemia - changes in metabolism and consequences for the myocyte. Molecular and Cellular Biochemistry, 180, pp.3-26.

Lochner, A., Huisamen, B., Klopper, J.F., Opie, L.H., King, L.M. and Du Toit, E.F., 1997. Myocardial metabolism. Cardiovascular Journal of South Africa (Suppl C45-C53).

King, L.M. and Opie, L.H., 1996. Does preconditioning act by glycogen depletion in the isolated rat heart? Journal of Molecular and Cellular Cardiology, 28, pp.2305-2321.

King, L.M. and Opie, L.H., 1996. Preconditioning - a reappraisal of protection. Basic Research Cardiology, 91, pp.5-7.

King, L.M. and Opie, L.H., 1996. Preconditioning - a reappraisal of protection. In: Heusch, G. (Ed.). New paradigms of coronary artery disease. Steinkopf Verlag, Darmstadt, pp.123-125.

King, L.M., Boucher, F.R. and Opie, L.H., 1995. Coronary flow and glucose delivery as determinants of contracture in the ischaemic myocardium. Journal of Molecular and Cellular Cardiology, 27, pp.701-720.

Von Oppell, U.O., King, L.M., du Toit, E.F., Owen, E.P., Reichart, B. and Opie, L.H., 1991. Effect of pH shifts induced by oxygenating crystalloid cardioplegic solutions. Annals of Thoracic Surgery, 52(4), pp.903-907.

Von Oppell, U.O., King, L.M., du Toit, E.F., Owen, E.P., Reichart, B. and Opie, L.H., 1991. Effect of oxygenation and consequent pH changes on the efficacy of St Thomas' Hospital cardioplegic solution. Journal of Thoracic and Cardiovascular Surgery, 102, pp.396-404.

Von Oppell, U.O., du Toit, E.F., King, L.M., Owen, E.P., Reichart, B. and Opie, L.H., 1991. St Thomas' Hospital cardioplegic solution. Beneficial effect of glucose and multidose reinfusions of cardioplegic solution. Journal of Thoracic and Cardiovascular Surgery, 102, pp.405-412.

Coetzee, W.A. and King, L.M., 1990. Electrophysiology of rat hearts and rabbit ventricular myocytes during reperfusion after transient ischaemia. In: Vereecke, J., von Bogaert, P.P. and Verdonck, F. (Eds.). Ionic currents and Ischaemia. Leuven University Press, pp.285-287.

Rabiner, E.A., Butkow, N. and King, L.M., 1990. Effect of electrical pacing and external calcium concentration on the contractile performance of the isolated perfused rat heart. South African Journal of Science, 86, pp.24-27.

Bonegio, R.G.B.M., Driver, H.S., King, L.M., Laburn, H.P. and Shapiro, C.M., 1988. Circadian temperature rhythm blunting and sleep composition. Acta Physiologica Scandinavica, 133 (Suppl 574), pp.44-47.

Cowie, R.L. and King, L.M., 1987. Pulmonary tuberculosis in corticosteroid-treated asthmatics. South African Medical Journal, 72, pp.849-850.