Dr Havovi Chichger

Course Leader

Senior Lecturer

Faculty:Faculty of Science & Technology

Department:Biomedical and Forensic Science

Location: Cambridge

Areas of Expertise: Life sciences

Havovi’s primary research focuses on cellular mechanisms which regulate the endothelium in human disease.

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havovi.chichger@anglia.ac.uk
View Havovi's profile on Research Gate

Background

In 2011, Havovi earned her doctorate in physiology from University College London, which focused on studying the role of renal and small intestinal glucose transport across the epithelium in metabolic syndrome and diabetes. During her studies, she developed an interest in the microvasculature complications associated with diabetes and took advantage of the opportunity to perform postdoctoral research at the Vascular Research Laboratory in Brown University.

As a postdoctoral fellow, Havovi's research developed into vascular dysfunction in settings of disease including respiratory disease. During her postdoctorate, she was awarded significant funding from the American Heart Association, published several peer-reviewed articles and participated in numerous clinical and basic research conference presentations (including invited and peer-reviewed oral presentations) on renal glucose transport, endocytosis, vascular function and respiratory disease.

Research interests

  • Renal and small intestinal glucose transport across the epithelium (diabetes, metabolic syndrome) 
  • Mechanisms regulated by artificial sweeteners and sweet taste receptors (diabetes, pulmonary diseases)
  • Endosomal trafficking in the vasculature (pulmonary diseases)
  • Protein phosphatase (PTP and SHP2) signalling (pulmonary diseases)
  • Protein kinases (PKC and MAPK) signalling (diabetes, pulmonary diseases)
  • Novel mechanisms regulating microvascular complications (diabetes, pulmonary diseases)

Areas of research supervision

  • Marie Houdmont, May-December 2010: research rotation, Biochemistry, class of 2011, University College London
  • Zhio Zhang, September 2010-March 2011: MSc student, Neuroscience, Physiology and Pharmacology Graduate Program, University College London
  • Hannibal Black, June-August 2012: research student from the NHLBI Short Term Training Grant for Minority Students, class of 2014, Claflin University
  • Myranda Myers, June-August 2014: research student from the NHLBI Short Term Training Grant for Minority Students, class of December 2014, Kutztown University
  • Geraldine Boni, June-August 2014: independent research, School of Engineering, class of 2015, Brown University

Mentored independently or with support from Principal Investigator

Qualifications

  • Teaching excellence certificate, Sheridan Centre, Brown University
  • PhD Physiology, University College London
  • BSc Biochemistry, King’s College London

Memberships, editorial boards

  • Associate Member, The Physiological Society UK, 2007-2011
  • Member, American Society of Nephrology, 2009-2011
  • Early Career Member, American Heart Association, 2012-present
  • Member, American Physiological Society, 2012-present
  • Member, American Thoracic Society, 2012-present

Selected recent publications

Chichger, H., Braza, J., Duong, H. and Harrington, E.O., 2015. SHP2 and FAK protein interactions regulate pulmonary endothelium barrier function. American Journal of Respiratory Cell and Molecular Biology, 52(6), pp.695-707.

Chichger, H., Vang, A., O’Connell, K., Zhang, P., Harrington, E.O., Mende, U. and Choudhary, G., 2015. PKC δ and βII regulate angiotensin II-mediated fibrosis through p38: a mechanism of RV fibrosis in pulmonary hypertension. American Journal of Physiology-Lung Cellular and Molecular Physiology, 308(8), L827-36.

Chichger, H., Braza, J., Duong, H. and Harrington, E.O., 2015. [p18] A novel adaptor protein, regulates pulmonary endothelial barrier function via enhanced endocytic recycling of VE-cadherin. FASEB J, 29(3), pp.868-81.

Jacquillet, G., Chichger, H., Unwin, R.J. and Shirley, D.G., 2013. Luminal proteolytic activation of the collecting duct epithelial sodium channel (ENaC) and its possible role in renal sodium reabsorption in vivo. Nephrology Dialysis Transplantation, 28(4), pp.839-45.

*Grinnell, K.L., *Chichger, H., Braza, J., Duong, H. and Harrington, E.O., 2012. Protection against LPS-induced pulmonary edema through the attenuation of PTP1B oxidation. American Journal of Respiratory Cell and Molecular Biology, 46, p.623-632.

Chichger, H., Grinnell, K.L., Casserly, B., Chung, C.S., Braza, J., Lomas-Neira, J., Ayala, A., Rounds, S., Klinger, J.R. and Harrington, E.O., 2012. Genetic Disruption of Protein Kinase Cδ (PKCδ) Reduces Endotoxin-Induced Lung Injury. American Journal of Physiology-Lung Cellular and Molecular Physiology, 303(10), p.L880-8.

Chichger, H., Grinnell, K.L. and Harrington, E.., 2012. Protein Kinase C Isoforms in the Formation of Focal Adhesion Complexes: Investigated by Cell Impedance. In: Wengou G. Jiang (Ed.). Electric Cell-Substrate Impedance Sensing and Cancer Metastasis. Springer.

Bueter, M., Miras, A.D., Chichger, H., Fenske, W., Ghatei, M.A., Bloom, S.R., Unwin, R.J., Lutz, T.A., Spector, A.C. and Le Roux, C.W., 2011. Alterations of sucrose preference after Roux-en-Y gastric bypass. Physiology & Behaviour, 104, pp.709-721.

Ceskova, P., Chichger, H., Wallace, M., Vojtesek, B. and Hupp, T.R., 2006. On the mechanism of sequence-specific DNA-dependent acetylation of p53: The acetylation motif is exposed upon DNA binding. Journal of Molecular Biology, 357, pp.442-456.

Recent presentations and conferences

The Endosome in Pulmonary Disease. Rhode Island Hospital Clinical Pulmonary Seminar, Brown University, February 2015.

A Role for the Endosome in Angiogenesis: Implications for Pulmonary Arterial Hypertension. Vascular Research Laboratory Seminar, Providence Veteran Affairs Medical Center, Providence, RI, October 2014.

Endocytic Trafficking in Sweet Taste Sensing. Department of Medicine, Imperial College London, England, February 2014.

PKCβII and δ regulate right ventricular fibrosis through p38 activation. Cardiovascular Research Center (CVRC), Brown University, November 2013.

FAK-SHP2 interplay regulates the Adherens Junction. Experimental Biology, Boston, April 2013.

Regulation of endocytosis in pulmonary edema formation. Rhode Island Hospital Clinical Pulmonary Seminar, Brown University, December 2012.

Vascular injury and permeability. Cardiovascular Research Center (CVRC), Brown University, June 2012.

Regulation of renal and small intestinal glucose transport across the epithelium in response to metabolic dysregulation. Department of Surgical Research, Brown University, February 2012.

GLUTs and SGLTs: how we reabsorb glucose. Annual Diabetes UK charity conference, London, England, November 2009.

The role of sweet taste sensing in the kidney. National Institute of Medical Research London, March 2009.