Dr Clett Erridge

Senior Lecturer

Faculty:Faculty of Science & Technology

Department:Biomedical and Forensic Science

Location: Cambridge

Courses taught: Biomedical Science

Clett is a Senior Lecturer in Biology of Disease.  His research aims to establish the molecular mechanisms connecting inflammation to lipid metabolism, particular in the context of coronary artery disease and other inflammatory conditions.

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Clett.Erridge@anglia.ac.uk

Background

Clett completed his BSc in Molecular Biology (1997), and PhD in Molecular Immunology (2003), at the University of Edinburgh. He then moved to Strathclyde University to take up a British Heart Foundation sponsored Junior Research Fellowship. In 2008, he moved to the University of Leicester to take a second Research Fellowship. During this time, Clett’s research focus progressed from an exploration of the impact of oxidised lipids and lipoproteins on innate immune signalling, to the mechanisms by which pattern-recognition receptors regulate lipid metabolism at the cellular and systemic levels. Currently, his work focuses particularly on the mechanisms connecting pattern-recognition receptor signalling with the induction of risk factors for chronic metabolic disease.

Research interests

  • Mechanisms connecting pattern-recognition receptor signalling to lipid metabolism in macrophages
  • Regulation of serum lipoprotein metabolism by Kupffer cell - hepatocyte cross-talk
  • Regulation of innate immune signalling by products of the intestinal and food microbiota
  • Genetic approaches to the identification of novel drug targets for metabolic disease
  • Drug discovery for pattern recognition receptors

Areas of research supervision

Interested in supervising PhD study in the following areas:
  • Roles of innate immune signalling in macrophage lipid metabolism and atherosclerosis
  • Regulation of reverse cholesterol transport by the acute phase response
  • Diet-dependent regulation of systemic inflammatory tone

Has supervised 4 MSc and 2 PhD students to successful completion of their studies in these areas.

Teaching

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BSc (Hons) Biomedical Science
Module Leader for Current Advances in Biomedical Science
Contribute to Clinical immunology
Contribute to Principles of Pathology
Contribute to Core Biology 2

Qualifications

PhD, Molecular Immunology, University of Edinburgh (2003)
BSc (Hons), Molecular Biology, University of Edinburgh (1997)

Memberships, editorial boards

Member of the British Atherosclerosis Society
Member of the British Society for Cardiovascular Research

Research grants, consultancy, knowledge exchange

Diet-dependent regulation of innate immune function in atherosclerosis. Erridge C (PI), Stover C. October 2013 to September 2016. Iraq government funded PhD studentship. £54,000

How do infections activate inflammation in MS? Role of TLR2. Gran B, Erridge C (CoI). March 2014 to February 2016. Italian MS society. €126,550

Investigation of the roles of dietary TLR-stimulants in murine atherogenesis. Erridge C (PI). January 2013 to September 2013. Wellcome Trust ISSF. £6,000

Human trial to investigate the link between food contamination with bacterial components and inflammation. Erridge C (PI). January 2010 to July 2010. Biobator pump priming fund. £10,000

Comparison of type I interferon responses in subjects homozygous for 9p21 variants. Erridge C (PI). April 2011 to December 2011. Leicester University Biomedical Research Unit. £10,000

A food or saliva test for risk of periodontitis, cardiovascular disease and diabetes. Erridge C (PI). May 2011 to January 2012. EMDA Innovation Fellowship. £15,169

Investigation of the mechanisms of foam cell formation in response to TLR-signalling. Erridge C (PI), A. Goodall. October 2009 to September 2012. University PhD Studentship. £43,770

Role of oxidised phospholipids in the resolution of inflammation. Erridge C (PI). April 2007 to May 2008. A University of Strathclyde RDF bridging fund. £8,800

Role of oxidative stress in arterial TLR2 expression. Erridge C (PI), Spickett CM. January 2005 to July 2005. Funded by Tenovus. £4,535

Role of TLR4 mutations in cytokine responses to bacterial pathogens. Erridge C (PI), Spickett CM. June 2004 to August 2004. Funded by Nuffield. £2,500

Role of smoking and high fat diet on low grade endotoxaemia. Erridge C (PI), Attina T, Spickett C, Webb D. April 2005 to December 2005. Scottish Executive Chief Scientist Office. £17,995

Roles of Toll-like receptors in atherosclerosis. Erridge C, Webb D, Spickett C. Oct ‘03 to Oct ‘06. BHF sponsored Junior Fellowship. £92,589

Selected recent publications

Herieka M, Faraj TA, Erridge C. (2016) Reduced dietary intake of pro-inflammatory Toll-like receptor stimulants favourably modifies markers of cardiometabolic risk in healthy men. Nutr Metab Cardiovasc Dis 26:194-200.

Nelson CP, Schunkert H, Samani NJ, Erridge C. (2015) Genetic analysis of leukocyte type-I interferon production and risk of coronary artery disease. Arterioscler Thromb Vasc Biol 35:1456-62.

Erridge C, Gracey J, Braund PS, Samani NJ. (2013) The 9p21 locus does not affect risk of coronary artery disease through induction of type 1 interferons. J Am Coll Cardiol 62:1376-81.

Herieka M, Erridge C. (2013) High-fat meal induced postprandial inflammation. Mol Nutr Food Res 58:136-46.

Nicolaou G, Goodall AH, Erridge C. (2012) Diverse bacteria promote macrophage foam cell formation via TLR-dependent lipid body synthesis. J Atheroscler Thromb 19:137-48.

Erridge C. (2011) Diet, commensals and the intestine as sources of pathogen-associated molecular patterns in atherosclerosis, type II diabetes and non-alcoholic fatty liver disease. Atherosclerosis 216:1-6.

Erridge C. (2010) The capacity of foodstuffs to induce innate immune activation of human monocytes in vitro is dependent on food content of stimulants of Toll-like receptors 2 and 4. Br J Nutr 20:1-9.

Erridge C. (2010) Endogenous ligands of TLR2 and TLR4: agonists or assistants? J Leukoc Biol 87:989-99.

Nicolaou G, Erridge C. (2010) Toll-like receptor-dependent lipid body formation in macrophage foam cell formation. Curr Opin Lipidol 21:427-33.

Erridge C, Duncan SH, Bereswill S, Heimesaat MM. (2010) The induction of colitis and ileitis in mice is associated with marked increases in intestinal concentrations of stimulants of TLRs 2, 4 and 5. PLoS ONE 5:e9125.

Erridge C, Samani NJ. (2009) Saturated fatty acids do not directly stimulate Toll-like receptor signaling. Arterioscler Thromb Vasc Biol 29:1944-9.

Erridge C. (2009) Oxidised phospholipid inhibition of LPS-signalling: a good side to the bad guys? Arterioscler Thromb Vasc Biol 29:337-338.

Erridge C. (2009) CD36: Promotion from scavenger receptor to mediator of migration? Cardiovasc Res 83:5-6.

Erridge C. (2009) The roles of Toll-like receptors in atherosclerosis. J Innate Immun 1:340-9.

Erridge C, Kennedy S, Spickett CM, Webb DJ. (2008) Oxidized phospholipid inhibition of toll-like receptor (TLR) signaling is restricted to TLR2 and TLR4: roles for CD14, LPS-binding protein, and MD2 as targets for specificity of inhibition. J Biol Chem 283:24748-59.

Erridge C. (2008) The roles of pathogen-associated molecular patterns in atherosclerosis. Trends Cardiovasc Med 18:52-6.

Erridge C, Burdess A, Jackson AJ, Murray C, Riggio M, Lappin D, Milligan S, Spickett CM, Webb DJ. (2008) Vascular cell responsiveness to Toll-like receptor ligands in carotid atheroma. Eur J Clin Invest 38:713-20.

Erridge C, Attina T, Spickett CM, Webb DJ. (2007) A high-fat meal induces low-grade endotoxemia: evidence of a novel mechanism of postprandial inflammation. Am J Clin Nutr 86:1286-92.

Erridge C, Spickett CM, Webb DJ. (2007) Non-enterobacterial endotoxins stimulate human coronary artery but not venous endothelial cell activation via Toll-like receptor 2. Cardiovasc Res 73:181-9.

Erridge C, Webb DJ, Spickett CM. (2007) Toll-like receptor 4 signalling is neither sufficient nor required for oxidised phospholipid mediated induction of interleukin-8 expression. Atherosclerosis 193:77-85.

Erridge C, Stewart J, Poxton IR. (2003) Monocytes heterozygous for the Asp299Gly and Thr399Ile mutations in the Toll-like receptor 4 gene show no deficit in lipopolysaccharide signalling. J Exp Med 197:1787-91.

Recent presentations and conferences

2016 - Cambridge University - Invited speaker
2013 - British Atherosclerosis Society - Invited speaker
2011 - Cambridge University - Invited speaker
2010 - Queen's University Belfast - Invited speaker
2010 - Reading University - Invited speaker
2008 - Rowett Institute - Aberdeen - Invited speaker
2008 - Scottish Cardiovascular Forum - Edinburgh - Invited speaker
2007 - Society for General Microbiology - Edinburgh - Invited speaker
2007 - Technical University - Graz - Invited speaker
2007 - Scottish Lipid Discussion Group - Glasgow - Invited speaker
2007 - Celcus - Glasgow - Invited speaker

Media experience

Outreach activities include contributions to ‘The Conversation’ and interviews with media outlets including l’Edition du Soir, the Daily Mail, Medicalresearch.com and NRT-TV.