New funding awarded through the Fight for Sight Small Grant Awards scheme will help researchers investigate some of the causes of sight loss and improve ways of detecting eye disease.

Fight for Sight, the UK's leading eye research charity, has awarded six new grants of £15,000 to support research in the following areas:

Informing health care provision

Professor Rupert Bourne and Dr Holly Price, based at the Vision and Eye Research Unit (VERU) of Anglia Ruskin University in Cambridge, will use their Fight for Sight Small Grant Award to analyse data collected through the Global Burden of Disease, Injuries and Risk Factors study to provide up-to-date estimates of the incidence and prevalence of sight loss worldwide. The information will be used to plan eye care service provision.

Enabling earlier detection of glaucoma

Glaucoma is the second leading cause of sight loss worldwide and affects one in 50 people over the age of 40 in the UK. Damage to the optic nerve caused by glaucoma cannot be reversed but early detection enables earlier treatment which can slow down the progression of the disease and prevent permanent sight loss.

Dr Thomas Jehle and Mr David Broadway at the Glaucoma Research Unit of the Norfolk and Norwich University Hospital will use their grant to test the effectiveness of the Pattern Electroretinogram (PERG) technique for detecting early stage glaucoma. It is hoped the new technique can also be used to helps doctors determine cases where the disease is likely to progress and new treatment is needed.

Dr Julie Albon, Professor James Morgan and Professor Rachel North, from the School of Ophthalmology and Vision Science at the University of Cardiff, will use their Fight for Sight Small Grant Award to detect the early stages of optic nerve damage caused by glaucoma using the recently developed SD-OCT imaging technique.

Improving the success of corneal transplants

Corneal transplants are used to restore sight in patients affected by corneal disease or injury. Although the procedure has a good success rate, sometimes the new cornea is rejected and the transplant fails.

Consultant ophthalmologist, Mr Frank Larkin, and optometrist, Mr Scott Chin Hung Hau, based at Moorfields Eye Hospital are developing a method of predicting the risk of corneal graft rejection following corneal transplants. The new non-invasive technique will measure the number of white blood cells found in the cornea following transplantation to see if there is a correlation between white blood cell count and corneal graft rejection. If successful, the technique could be used to identify patients at risk of corneal rejection and improve the success rate of transplantations.

Understanding the causes of inherited retinal disease

Professors Tony Moore and John Yates from the UCL Institute of Ophthalmology will use their Fight for Sight Small Grant Award to look at the causes of macular dystrophy - an inherited eye condition which affects the central area of the retina (the macular). Macular dystrophies can cause sight loss in children from a young age.

The team at the UCL Institute of Ophthalmology are using advanced gene sequencing techniques to identify the faulty gene responsible for macular dystrophy being passed down through families. The project will give them a better understanding of the causes of the diseases and the way it develops and, if successful, could lead to new gene replacement therapy treatments.

Dr Kaoru Fujinami and Dr Andrew Webster based at the UCL Institute of Ophthalmology and Moorfields Eye Hospital are investigating abnormalities in the gene ABCA4 which causes Stargardt's disease. Stargardt's is one of the most common forms of inherited retinal disease which results in progressive sight loss.

Recent clinical trials have shown that gene replacement therapy is safe for patients with the inherited disease Leber's congenital amaurosis. With funding from Fight for Sight, the team aims to discover more about the faulty gene that causes Stargardt's which could lead to a new gene replacement therapy for this disease.

Fight for Sight is committed to supporting world-class research into the prevention and treatment of blindness and eye disease. For more information about the charity and the current research programme, visit www.fightforsight.org.uk/research.