Myopia research
Myopia : factors that influence the progression of myopia
Professor Shahina Pardhan, Dr Peter Allen, Dr Sheila Rae, Dr Richard Calver, Dr Silvia Cirstea, Dr Holly Price, Heather Shorrock, Dr Ian van der Linde, Dharani RamamurthyCollaboration between Myopia and Visual Function group, Department of Optometry and Ophthalmic Dispensing and Department of Computing and Technology.
Current activities:
- To identify optical factors that are associated with myopic progression
- To investigate how ocular biometry and eye shape are associated with myopic progression
- To investigate how optical and biometric factors relate to the progression of myopia.
- To investigate how family history, IQ and near-work affects myopia progression.
- To identify the role of peripheral refraction in Myopia.
Outcomes:
We have investigated factors related to the accommodation system both cross-sectionally and longitudinally in myopes. Our researchers have identified reasons for such deficits in accommodation and were the first to show that reduced accommodative response in myopes may be due to a decrease in sensitivity to negative lens blur, and that the optimum focus for a system which drives accommodation is more negative in myopes.
We are investigating potential treatments for myopia, mainly vision training and specially designed contact lenses to improve the accuracy of accommodation during near-work. Our preliminary data of three months of treatment indicate that the treatment has been successful in improving the accommodative responses of myopes. We are the first ones to show that accommodative facility and lag of accommodation are independently associated with the progression of myopia in young adults
Recently, the contribution of peripheral refractive error to myopia progression has received a great deal of attention, and we have contributed to this debate by demonstrating how these errors vary in the nasal and temporal retina in distance and near vision. Our study in India has examined the interaction between family history of myopia and amount of near-work, showing that myopes with a family history of myopia progress more than those without, and also highlighting association between myopia and IQ scores.
The group is part of a large research consortium based in Australia and funded by the government of Australia (the Vision Co-operative Research Centre) with international research partners in the University of Houston, Queensland University of Technology, the University of Sydney, University of Melbourne, the University of New South Wales, the Pennsylvania College of Optometry, Manchester University and Sankar Netralaya Hospital (Chennai), LV Prasad Institute in India.
Grants:
Vision CRC to the Myopia Research Group through the Government of Australia Research Co-operative grant (£201,301).
University of California, Berkeley Clinical Scientists Development Program travel grant award.
Vision CRC travel grants.
We have investigated factors related to the accommodation system both cross-sectionally and longitudinally in myopes. Our researchers have identified reasons for such deficits in accommodation and were the first to show that reduced accommodative response in myopes may be due to a decrease in sensitivity to negative lens blur, and that the optimum focus for a system which drives accommodation is more negative in myopes.
We are investigating potential treatments for myopia, mainly vision training and specially designed contact lenses to improve the accuracy of accommodation during near-work. Our preliminary data of three months of treatment indicate that the treatment has been successful in improving the accommodative responses of myopes. We are the first ones to show that accommodative facility and lag of accommodation are independently associated with the progression of myopia in young adults
Recently, the contribution of peripheral refractive error to myopia progression has received a great deal of attention, and we have contributed to this debate by demonstrating how these errors vary in the nasal and temporal retina in distance and near vision. Our study in India has examined the interaction between family history of myopia and amount of near-work, showing that myopes with a family history of myopia progress more than those without, and also highlighting association between myopia and IQ scores.
The group is part of a large research consortium based in Australia and funded by the government of Australia (the Vision Co-operative Research Centre) with international research partners in the University of Houston, Queensland University of Technology, the University of Sydney, University of Melbourne, the University of New South Wales, the Pennsylvania College of Optometry, Manchester University and Sankar Netralaya Hospital (Chennai), LV Prasad Institute in India.
Grants:
Vision CRC to the Myopia Research Group through the Government of Australia Research Co-operative grant (£201,301).
University of California, Berkeley Clinical Scientists Development Program travel grant award.
Vision CRC travel grants.
Publications
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Allen, P.M., Radhakrishnan, H., Rae, S., Calver, R.I., Theagarayan, B.T., Nelson, P., Osuobeni, E., Sailaganathan, A, Price, H. and O'Leary, D.J. (2009). Aberration control and vision training as an effective means of improving accommodation in myopes. Investigative Ophthalmology and Visual Science (in press).
Allen, P., and O'Leary, D.J. (2006) Accommodation functions: Co-dependency and relationship to refractive error. Vision Research, 46 (4), 491-505.
Allen, P.M., Radhakrishnan, H., O'Leary, D.J. (2003) Repeatability and Validity of the Powerfractor and the Nidek AR600-A in an adult population with healthy eyes. Optometry and Vision Science, 80,245-251.
Allen, P., and O'Leary, D.J. (2006) Accommodation functions: Co-dependency and relationship to refractive error. Vision Research, 46 (4), 491-505.
Allen, P.M., Radhakrishnan, H., O'Leary, D.J. (2003) Repeatability and Validity of the Powerfractor and the Nidek AR600-A in an adult population with healthy eyes. Optometry and Vision Science, 80,245-251.
Calver, R (2010). The Health and Social Security Act 1984 and the price of spectacles among corporate practices in the United Kingdom (1980 - 2007): a review. Ophthalmic and Physiological Optics, 30, 113-123
Calver, R, Radhakrishnan, H, Osuobeni, E, O'Leary D (2007). Peripheral refraction for distance and near vision in emmetropes and myopes. Ophthal. Phyisol. Opt., 27, 584-593.
Manolache Cirstea, S., Kung, S.Y., McCormick, M., Aggoun, A (2003). 3D-object reconstruction from planar recorded data of 3D-integral images, The J. of VLSI Signal Proc. Systems, Kluwer Academics, vol. 35, pp. 5-17.
Manolache, S., Aggoun, A., McCormick, M., Davies, N. (2001), Analytical Model of a 3D-integral camera system using circular and hexagonal based hemi-spherical microlenses, J. Opt. Soc. Am. A, vol. 18, 1814-1821.
O'Leary, D.J., Allen, P.M. (2001) Facility of accommodation in myopia. Ophthalmic and Physiological Optics 21 (5), 352-355.
Manolache, S., Aggoun, A., McCormick, M., Davies, N. (2001), Analytical Model of a 3D-integral camera system using circular and hexagonal based hemi-spherical microlenses, J. Opt. Soc. Am. A, vol. 18, 1814-1821.
O'Leary, D.J., Allen, P.M. (2001) Facility of accommodation in myopia. Ophthalmic and Physiological Optics 21 (5), 352-355.
Radhakrishnan, H., Allen, P.M. and Charman, W.N. (2007) Dynamics of accommodative facility in myopes. Investigative Ophthalmology and Visual Science 48(9), pp 4375-4382.
Radhakhrishnan, H., Pardhan, S. (2006). Contrast detection in noise with positive and negative defocus in myopes. Vision Research 46 2949-2955.
Radhakrishnan, H., Pardhan, S., Calver, R.I., O'Leary, D.J. (2004). Effect of positive and negative defocus on contrast sensitivity in myopes and non-myopes. Vision Research. 44, 1869-1878.
Radhakrishnan, H., Pardhan, S., Calver, R.I., O'Leary, D.J. (2004). Unequal reduction in visual acuity with positive and negative defocusing lenses in myopes. Optometry & Vision Science. 81, 14-17.
Rae, S., Allen, P.M., Radhakrishnan, H., Theagarayan, B.T., Price, H, Sailaganathan, A, Calver, R.I. and O'Leary, D.J. (2009). Increasing negative spherical aberration with soft contact lenses improves high and low contrast visual acuity in young adults. Ophthalmic and Physiological Optics 29: 593-601.
Radhakrishnan, H., Pardhan, S., Calver, R.I., O'Leary, D.J. (2004). Unequal reduction in visual acuity with positive and negative defocusing lenses in myopes. Optometry & Vision Science. 81, 14-17.
Rae, S., Allen, P.M., Radhakrishnan, H., Theagarayan, B.T., Price, H, Sailaganathan, A, Calver, R.I. and O'Leary, D.J. (2009). Increasing negative spherical aberration with soft contact lenses improves high and low contrast visual acuity in young adults. Ophthalmic and Physiological Optics 29: 593-601.
Rae, S, Latham, K and Norgett, Y (2009). Variability in visual acuity with dioptric blur: dependence on test chart design. Ophthalmic and Physiological Optics 2009.
Theagarayan, B.B., Radhakrishnan, H., Allen, P.M., Calver, R.I., Rae, S.R., O'Leary D.J. (2009) The effect of altering spherical aberration on the static accommodative response. Ophthalmic and Physiological Optics , 29, 65-71.
Allen PM, Radhakrishnan H, Price H, Rae S, Theagarayan B, Calver RI, Sailoganathan A, Latham K and O'Leary DJ. (2013) A randomised clinical trial to assess the effect of a dual treatment on myopia progression: The Cambridge Anti-Myopia Study. Ophthalmic Physiol Opt 33: 267?276
Radhakrishnan H, Allen PM, Calver RI, Theagarayan B, Price H, Rae S, Sailoganathan A and O'Leary DJ.(2013) Peripheral refractive changes associated with myopia progression. Invest Ophthalmol Vis Sci.; 54(2):1573-1581
Radhakrishnan H, Allen PM, Calver RI, Theagarayan B, Price H, Rae S, Sailoganathan A and O'Leary DJ.(2013) Peripheral refractive changes associated with myopia progression. Invest Ophthalmol Vis Sci.; 54(2):1573-1581
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